Cascara sagrada (Rhamnus purshiana) bark contains anthraquinones that stimulate bowel movements. While historically very popular in over-the-counter laxatives, the FDA eventually ruled it non-GRAS (Generally Recognized as Safe) for OTC drugs due to a lack of modern safety data, though it remains widely available as a dietary supplement.
Clinical Summary
Effective for short-term constipation relief, but growing safety concerns regarding long-term use and potential liver toxicity have limited its modern clinical endorsement.
Dosage Guidelines
Doses vary by preparation; historically used short-term. Not recommended for more than 7 consecutive days.
Safety & Side Effects
Severe cramps, diarrhea, electrolyte imbalance, and potential hepatotoxicity (liver damage) with chronic use.
Known Interactions
Interacts with cardiac glycosides (like digoxin), diuretics, and corticosteroids due to the risk of potassium loss.
Medical Disclaimer
The information provided in this clinical review is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
*These statements have not been evaluated by the Food and Drug Administration (FDA). This product or ingredient is not intended to diagnose, treat, cure, or prevent any disease.
Always consult your physician or other qualified health provider with any questions you may have regarding a medical condition, or before beginning any new diet, fitness, supplement, or treatment regimen, especially if you have pre-existing medical conditions or are taking prescribed medications.
