Quick Reference
- Scientific Rating
-
4.6/ 5.0
- Primary Mechanism
- Modulation of hepatic cytochrome P450 enzymes to optimize the ratio of estrogen metabolites
- Standardized Form
- Microencapsulated or absorption-enhanced DIM
Diindolylmethane (DIM) is a bioactive compound formed during the digestion of indole-3-carbinol, found in cruciferous vegetables like broccoli. DIM actively modulates estrogen metabolism in the liver. It shifts the enzymatic breakdown of estrogen away from the highly proliferative 16-alpha-hydroxyestrone pathway and towards the more protective and benign 2-hydroxyestrone pathway, mitigating systemic symptoms of estrogen dominance.
Table of Contents
Clinical Summary
Utilized broadly in functional medicine to address estrogen dominance, fibrocystic breast changes, and hormonal acne. Supported by clinical trials showing favorable shifts in urinary estrogen metabolite ratios.
Dosage Guidelines
100mg to 200mg daily, usually taken with food to enhance absorption.
Safety & Side Effects
Harmless darkening or amber coloring of urine. Mild, transient headaches can occur during initial use as estrogen clearance increases.
Known Interactions
Can alter the metabolism of certain medications processed by CYP1A2 liver enzymes.
Scientific References
- 1
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Medical Disclaimer
The information provided in this clinical review is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
*These statements have not been evaluated by the Food and Drug Administration (FDA). This product or ingredient is not intended to diagnose, treat, cure, or prevent any disease.
Always consult your physician or other qualified health provider with any questions you may have regarding a medical condition, or before beginning any new diet, fitness, supplement, or treatment regimen, especially if you have pre-existing medical conditions or are taking prescribed medications.
