Folate (Vitamin B9) is required for one-carbon metabolism and methylation reactions throughout the body. 5-MTHF (5-methyltetrahydrofolate) is the biologically active form that does not require conversion by the MTHFR enzyme, making it preferable for individuals with common MTHFR gene variants.
Clinical Summary
Clinically preferred over synthetic folic acid for individuals with MTHFR polymorphisms, since it bypasses the rate-limiting conversion step.
Dosage Guidelines
400mcg to 800mcg (DFE) daily for general supplementation.
Safety & Side Effects
Generally very safe; high-dose synthetic folic acid (not 5-MTHF) has been associated with masking B12 deficiency symptoms.
Known Interactions
May interact with methotrexate and certain anti-seizure medications; consult a physician if on these drugs.
Medical Disclaimer
The information provided in this clinical review is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
*These statements have not been evaluated by the Food and Drug Administration (FDA). This product or ingredient is not intended to diagnose, treat, cure, or prevent any disease.
Always consult your physician or other qualified health provider with any questions you may have regarding a medical condition, or before beginning any new diet, fitness, supplement, or treatment regimen, especially if you have pre-existing medical conditions or are taking prescribed medications.
