Independent reviews · Updated weekly Editorial & affiliate disclosures
HFL Health Findings Lab

Histidine

An essential amino acid that serves as a precursor to histamine and plays a role in tissue repair and immune function.

Clinical Profile

Histidine is converted into histamine, an important signaling molecule in immune responses and gastric acid regulation. It is one of the nine essential amino acids required for complete human protein synthesis.

Clinical Summary

Considered essential for complete muscle protein synthesis; research on isolated supplementation is more limited compared to the branched-chain amino acids.

Dosage Guidelines

500mg to 1,000mg daily depending on dietary intake and intended use.

Safety & Side Effects

Very well tolerated at standard supplemental doses.

Known Interactions

No major known drug interactions at supplemental doses.

Medical Disclaimer

The information provided in this clinical review is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.

*These statements have not been evaluated by the Food and Drug Administration (FDA). This product or ingredient is not intended to diagnose, treat, cure, or prevent any disease.

Always consult your physician or other qualified health provider with any questions you may have regarding a medical condition, or before beginning any new diet, fitness, supplement, or treatment regimen, especially if you have pre-existing medical conditions or are taking prescribed medications.

Articles discussing Histidine

Get new reviews in your inbox — weekly, never spammy.

Join our community of readers who use Health Findings Lab to cut through supplement marketing noise.