Licorice Root (Glycyrrhiza glabra) contains glycyrrhizin, a compound with anti-inflammatory properties in the digestive tract. Long-term or high-dose use can influence cortisol metabolism and sodium/potassium balance, which is why deglycyrrhizinated (DGL) forms are often preferred.
Clinical Summary
Traditional and clinical evidence supports licorice root for digestive comfort; DGL forms are used specifically to avoid the blood-pressure-related risks of glycyrrhizin.
Dosage Guidelines
300mg to 400mg of DGL extract, chewed before meals; whole-root extract doses vary by product.
Safety & Side Effects
Can raise blood pressure and cause potassium loss with prolonged, high-dose use of non-DGL forms.
Known Interactions
Can interact with blood pressure medications, diuretics, and corticosteroids; individuals with hypertension should avoid non-DGL forms.
Medical Disclaimer
The information provided in this clinical review is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
*These statements have not been evaluated by the Food and Drug Administration (FDA). This product or ingredient is not intended to diagnose, treat, cure, or prevent any disease.
Always consult your physician or other qualified health provider with any questions you may have regarding a medical condition, or before beginning any new diet, fitness, supplement, or treatment regimen, especially if you have pre-existing medical conditions or are taking prescribed medications.
