Magnesium L-Threonate (MgT) binds magnesium to L-Threonic acid, a vitamin C metabolite. This unique molecular structure allows it to effectively cross the blood-brain barrier (BBB) and elevate magnesium concentration in the cerebrospinal fluid, which standard magnesium salts cannot do efficiently. Elevated brain magnesium supports NMDA receptor function, critical for synaptic plasticity and memory formation.
Clinical Summary
Seminal research published in Neuron demonstrated this compound significantly raises brain magnesium levels, and it is linked to supporting synaptic density, memory retrieval, and reduced neuro-inflammation.
Dosage Guidelines
1,500mg to 2,000mg daily in split doses (providing roughly 144mg of elemental magnesium), with a portion often taken before bedtime.
Safety & Side Effects
Generally well tolerated; high doses of any magnesium form may cause mild gastrointestinal discomfort, though less frequently than magnesium citrate or oxide.
Known Interactions
Can interfere with the absorption of bisphosphonates and certain antibiotics (tetracyclines, quinolones); space doses by 2-4 hours.
Medical Disclaimer
The information provided in this clinical review is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
*These statements have not been evaluated by the Food and Drug Administration (FDA). This product or ingredient is not intended to diagnose, treat, cure, or prevent any disease.
Always consult your physician or other qualified health provider with any questions you may have regarding a medical condition, or before beginning any new diet, fitness, supplement, or treatment regimen, especially if you have pre-existing medical conditions or are taking prescribed medications.
