Piperine, the primary alkaloid in black pepper (Piper nigrum), inhibits certain drug-metabolizing enzymes in the gut and liver, which slows the breakdown of co-administered compounds and increases their systemic absorption.
Clinical Summary
Clinical studies show piperine can meaningfully increase the bioavailability of co-administered compounds such as curcumin and certain fat-soluble antioxidants.
Dosage Guidelines
5mg to 20mg per serving, taken alongside the target nutrient or botanical.
Safety & Side Effects
Generally safe at supplemental doses; may cause mild heartburn in sensitive individuals.
Known Interactions
Because it inhibits CYP450 enzymes, piperine can increase blood levels of many prescription medications; consult a physician if taking prescription drugs metabolized by the liver.
Medical Disclaimer
The information provided in this clinical review is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
*These statements have not been evaluated by the Food and Drug Administration (FDA). This product or ingredient is not intended to diagnose, treat, cure, or prevent any disease.
Always consult your physician or other qualified health provider with any questions you may have regarding a medical condition, or before beginning any new diet, fitness, supplement, or treatment regimen, especially if you have pre-existing medical conditions or are taking prescribed medications.
