Quick Reference
- Scientific Rating
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3.7/ 5.0
- Primary Mechanism
- Antioxidant polyphenol proposed to activate sirtuin (SIRT1) signaling and modulate inflammatory and metabolic pathways
- Standardized Form
- Trans-resveratrol extract standardized to 98% or greater trans-resveratrol content, typically sourced from Polygonum cuspidatum
Resveratrol is a stilbene polyphenol produced by certain plants, including grapes, in response to environmental stress or fungal infection, and is most commonly extracted from Japanese knotweed (Polygonum cuspidatum) for supplement use. It gained early mainstream attention through the "French Paradox" theory linking red wine consumption to cardiovascular benefit, which spurred substantial research into its antioxidant and cellular signaling properties, including proposed activation of sirtuin pathways associated with longevity in animal models. Human clinical research has since concentrated more heavily on measurable cardiovascular and metabolic endpoints, such as blood pressure and lipid profiles, than on the longevity claims that originally drove its popularity.
Table of Contents
Clinical Summary
Meta-analyses of randomized controlled trials report modest but statistically significant reductions in blood pressure and improvements in markers of insulin resistance, particularly in individuals with type 2 diabetes or metabolic syndrome. Evidence for effects in healthy individuals without existing metabolic dysfunction is comparatively weaker.
Dosage Guidelines
150-1000 mg/day across clinical trials, with most positive cardiovascular findings observed at 150-500 mg/day taken with food to improve absorption.
Safety & Side Effects
Generally well tolerated at studied doses; gastrointestinal upset (nausea, diarrhea) has been reported at higher doses (over 1 g/day).
Known Interactions
May have mild antiplatelet/anticoagulant activity; caution advised alongside blood-thinning medications. May also interact with drugs metabolized by CYP450 enzymes.
Scientific References
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1
https://pubmed.ncbi.nlm.nih.gov/29359958/Source: pubmed.ncbi.nlm.nih.gov
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2
https://pmc.ncbi.nlm.nih.gov/articles/PMC10276340/Source: pmc.ncbi.nlm.nih.gov
Medical Disclaimer
The information provided in this clinical review is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
*These statements have not been evaluated by the Food and Drug Administration (FDA). This product or ingredient is not intended to diagnose, treat, cure, or prevent any disease.
Always consult your physician or other qualified health provider with any questions you may have regarding a medical condition, or before beginning any new diet, fitness, supplement, or treatment regimen, especially if you have pre-existing medical conditions or are taking prescribed medications.