St. John's Wort (Hypericum perforatum) is a flowering plant with a long history of use for mental health. Its active compounds, hypericin and hyperforin, are believed to work similarly to standard SSRI antidepressants by increasing the availability of serotonin, dopamine, and norepinephrine in the brain.
Clinical Summary
Extensively studied in Europe; numerous meta-analyses show it is superior to placebo and similarly effective to standard antidepressants for mild-to-moderate depression, often with fewer side effects.
Dosage Guidelines
300mg three times daily (900mg total). Requires 3-6 weeks of consistent use to notice full mood-lifting effects.
Safety & Side Effects
Can cause increased sensitivity to sunlight (photosensitivity), dry mouth, dizziness, and mild gastrointestinal symptoms.
Known Interactions
DANGEROUS INTERACTIONS: It is a potent inducer of the CYP3A4 enzyme, meaning it clears many drugs out of the body too quickly. It severely interacts with birth control pills, immunosuppressants, and conventional antidepressants (risk of Serotonin Syndrome).
Medical Disclaimer
The information provided in this clinical review is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
*These statements have not been evaluated by the Food and Drug Administration (FDA). This product or ingredient is not intended to diagnose, treat, cure, or prevent any disease.
Always consult your physician or other qualified health provider with any questions you may have regarding a medical condition, or before beginning any new diet, fitness, supplement, or treatment regimen, especially if you have pre-existing medical conditions or are taking prescribed medications.